Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

Periodontal regeneration is a complex goal, which commonly pursued with combination of surgical techniques, biomaterials, and bioactive compounds. One such compound enamel matrix derivative (EMD), medical substance that extracted from porcine tooth germs contains several protein fractions BMP- TGF-β-like action. Activation TGF-β signaling required for EMD activity on cells tissues, growing body evidence indicates largely relies this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as tool to promote bone formation osteoblast activity, because recent studies reported the effects EMFs require primary cilia, by modulating presence membrane-bound receptors (e.g., BMP) or signal mediators, it can be hypothesized application may increase cell sensitivity EMD: TGFBR also identified could make more responsive inducing display higher number cellular membrane.